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Contraindicated (one)pentobarbital will lower the extent or impact of lorlatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or impact of exemestane by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. For people receiving exemestane with a powerful CYP3A4 inducer the adv